We calculate the instantaneous firing rate of a stochastic integrate-and-fire neuron driven by an arbitrary time-dependent signal up to second order in the signal amplitude.For cosine signals, this weakly nonlinear theory Serving Spoons reveals: (i) a frequency-dependent change of the time-averaged firing rate reminiscent of frequency locking in de
Abstract Background Protein-DNA interaction governs a large number of cellular processes, and it can be altered by a small fraction of interface residues, i.e., the so-called hot spots, which account for most of the interface binding free energy.Accurate prediction of hot spots is critical to understand the principle of protein-DNA interactions.The
Derangement of the epidermal barrier lipids and dysregulated immune responses are key pathogenic features of atopic dermatitis (AD).The Th2-type cytokines interleukin IL-4 and IL-13 play a prominent role in AD by activating the Janus Kinase/Signal Transduction and Activator of Transcription (JAK/STAT) intracellular signaling axis.This study aimed t
Aims: To evaluate radiographically, the presence or absence of nutrient canals in controls and patients with periodontal diseases, and to correlate the number of nutrient canals with severity of bone loss.Materials and methods: A total number of 1000 patients were enrolled, in that 500 patients were of study group and 500 of control group, in both
The subject of the article is to present the regulations of the Polish legal order aimed at combating and preventing domestic violence and juxtapose them with the obligations under the provisions of the Istanbul Convention.The article aims to answer the FM question of whether the Polish legal system makes it possible to effectively combat and preve